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目的:观察参芎化瘀胶囊对血管性痴呆模型大鼠学习记忆行为的影响。方法:将60只健康SD大鼠随机分为正常组、假手术组、模型组、喜得镇0.6 mg·kg-1治疗组、复方丹参270 mg·kg-1治疗组和参芎化瘀胶囊480 mg·kg-1治疗组6个组。均ig给药,每日1次,术前预防给药7 d,术后继续给药28 d。采用反复夹闭、再通双侧颈总动脉同时ip硝普钠制备大鼠血管性痴呆模型,应用Morris水迷宫检测各组大鼠学习记忆行为。结果:与正常组及假手术组相比,模型组大鼠逃避潜伏期时间延长(P<0.01,P<0.01),撤走安全平台后穿越平台的次数及在原平台象限停留时间均减少(均P<0.01)。与模型组比较,各药物治疗组大鼠逃避潜伏期时间缩短(P<0.05,P<0.01),撤走安全平台后穿越平台的次数及在原平台象限停留时间均增多(均P<0.05)。参芎化瘀胶囊组大鼠逃避潜伏期时间较喜得镇组短(P<0.05),与复方丹参组之间差异无显著性。结论:参芎化瘀胶囊能改善血管性痴呆大鼠的学习记忆能力。
Objective: To observe the effect of Shenxionghuayu capsule on learning and memory in vascular dementia model rats. Methods: Sixty healthy SD rats were randomly divided into normal group, sham operation group, model group, xidede 0.6 mg · kg-1 treatment group, Fufang Danshen 270 mg · kg-1 treatment group and Shenxionghuayu capsule 480 mg · kg-1 treatment group 6 groups. All ig administration, once a day, preoperative prophylaxis for 7 days, 28 days after surgery. The rat model of vascular dementia was established by repeated clipping, then the common carotid arteries of both sides and sodium nitroprusside. Morris water maze was used to detect the learning and memory behaviors of rats in each group. Results: Compared with the normal group and the sham operation group, the escape latency of the model group was prolonged (P <0.01, P <0.01), the number of traversing the platform after withdrawing the safety platform and the dwelling time in the original platform quadrant decreased <0.01). Compared with the model group, the escape latency of rats in each drug treatment group was shortened (P <0.05, P <0.01), the number of traversing platform after withdrawing the safety platform and the residence time in the original platform quadrant increased (P <0.05). Shenxionghuayu capsule group rats escape latency than Xidedezhen group (P <0.05), and the compound Salvia group was no significant difference. Conclusion: Shenxionghuayu capsule can improve the learning and memory ability of vascular dementia rats.