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目的:探讨高胆红素血症合并反应性血小板增多症新生儿的血小板参数和白细胞的变化及与黄疸程度的关系。方法:采用全自动血细胞分析仪测定354例高胆红素血症新生儿和36例正常新生儿的血小板计数(PLT)、血小板体积(MPV)、血小板分布宽度(PDW)、白细胞计数(WBC)。按黄疸程度分为轻度、中度、重度3组,比较反应性血小板增多症的发生率;按有无反应性血小板增多症分为反应性血小板增多症组和非反应性血小板增多症组,比较血小板参数和白细胞的变化。结果:354例高胆红素血症新生儿中合并反应性血小板增多症32例,发生率为9.04%,不同程度高胆红素血症新生儿反应性血小板增多症发生率比较差异无统计学意义(P>0.05)。高胆红素血症新生儿反应性血小板增多症组MPV高于高胆红素血症新生儿非反应性血小板增多症组(t=0.551,P<0.05),两组PDW、WBC比较差异均无统计学意义(P>0.05)。结论:高胆红素血症新生儿合并反应性血小板增多症时提示骨髓巨核细胞处于增生状态,其发生率与黄疸的程度无关。
Objective: To investigate the changes of platelet parameters and white blood cells in neonates with hyperbilirubinemia complicated with reactive thrombocythemia and their relationship with the degree of jaundice. Methods: The platelet count (PLT), platelet volume (MPV), platelet distribution width (PDW), white blood cell count (WBC) and blood count of 354 neonates with hyperbilirubinemia and 36 normal neonates were measured by automatic hematology analyzer . According to the degree of jaundice were divided into mild, moderate and severe group 3, the incidence of reactive thrombocythemia; by non-reactive thrombocythemia is divided into reactive thrombocythemia and non-reactive thrombocythemia group, Compare platelet parameters and leukocyte changes. Results: Among 354 neonates with hyperbilirubinemia, 32 cases were complicated with reactive thrombocythemia, the incidence was 9.04%. There was no significant difference in the incidence of neonatal reactive thrombocythemia between different degrees of hyperbilirubinemia Significance (P> 0.05). The MPV in neonates with hyperbilirubinemia was higher than that in neonates with hyperbilirubinemia (t = 0.551, P <0.05). There was significant difference in PDW and WBC between the two groups No statistical significance (P> 0.05). Conclusion: Hyperbilirubinemia in neonates with combined thrombocytopenia prompted bone marrow megakaryocytes in hyperplasia, the incidence has nothing to do with the degree of jaundice.