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目的:探讨ULBP2在胰腺癌组织中的表达及其与胰腺癌发生发展的相关性。方法:应用免疫组化检测ULBP2在胰腺癌中的表达,分析ULBP2与胰腺癌临床病理学特征的相关性。结果:ULBP2在胰腺癌组织中的阳性表达率为87.5%(35/40),正常胰腺组织阳性表达率为18.1%(2/11),癌组织与正常胰腺组差异显著(X2=21.865,P<0.01)。ULBP2在胰腺癌组织中的表达水平与肿瘤远处转移和分化程度密切相关(X2=4.322,6.400 P=0.038,0.041)。结论:ULBP2可能在胰腺癌发生发展中起重要作用,ULBP2有望成为胰腺癌免疫治疗的靶点。
Objective: To investigate the expression of ULBP2 in pancreatic cancer and its correlation with the occurrence and development of pancreatic cancer. Methods: The expression of ULBP2 in pancreatic cancer was detected by immunohistochemistry. The correlation between ULBP2 and clinicopathological characteristics of pancreatic cancer was analyzed. Results: The positive rate of ULBP2 expression in pancreatic cancer was 87.5% (35/40), while that in normal pancreatic tissue was 18.1% (2/11). There was significant difference between the two groups (X2 = 21.865, P <0.01). The expression level of ULBP2 in pancreatic cancer was closely related to the degree of distant metastasis and differentiation (X2 = 4.322, 6.400 P = 0.038,0.041). Conclusion: ULBP2 may play an important role in the development of pancreatic cancer. ULBP2 may be the target of immunotherapy for pancreatic cancer.