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本文从免疫、化学药物以及综合防治方法等三个方面概括了巨细胞病毒(CMV)感染的防治研究新进展。免疫方法在预防感染方面占有较大比重,除目前较为普遍的静脉滴注免疫球蛋白(IVIG)的被动免疫方法外,较有前途的发展方向是以各种疫苗特别是亚单位疫苗为代表的主动免疫方法。化学药物在防治方面的应用也相当广泛,目前常用的是磷甲酸(PFA)和丙氧鸟苷(DHPG),而叠氮胸苷和鬼臼乙叉甙(Etoposide,EPEG)具有一定的发展潜力。综合防治方法是将免疫与化学药物或两种以上的化学药物联用,这较单一的防治方法更为有效。
This article summarizes the new advances in the prevention and treatment of cytomegalovirus (CMV) infection from three aspects: immunology, chemical drugs and comprehensive prevention and treatment. Immunization methods occupy a large proportion of the prevention of infection, in addition to the more common intravenous immunoglobulin (IVIG) passive immunization methods, the more promising direction of development is based on a variety of vaccines, especially subunit vaccines as the representative Active immunization methods. Chemical drugs are also widely used in the prevention and treatment. Phosphoformate (PFA) and gonadoside (DHPG) are commonly used at present, and zidovudine and Etoposide (EPEG) have certain potential for development . Integrated prevention and treatment is the combination of immunization with chemical drugs or two or more chemicals, which is more effective than a single prevention and control method.