论文部分内容阅读
目的:观察“芪香”口服液抗呼吸道感染主要药效学作用。方法:采用家兔致热反应后的体温变化,观察“芪香”口服液的解热作用;采用小鼠耳廓肿胀试验,观察“芪香”口服液的抗炎作用;采用小鼠热板试验,观察“芪香”口服液的镇痛作用;采用体外抑菌实验,观察“芪香”口服液对常见呼吸道细菌的抑菌作用。结果:“芪香”口服液对内毒素所致家兔发热模型具有退热作用,能抑制二甲苯所致小鼠耳廓炎性肿胀;可明显提高热板引起的小鼠痛阈值;对呼吸道常见的病原菌有一定的抑菌作用。结论:“芪香”口服液是抗呼吸道感染的有效药物,具有显著的解热、抗炎、镇痛、抗菌的作用。
Objective: To observe the main pharmacodynamic effects of “Qixiang” oral solution against respiratory tract infection. Methods: The changes of body temperature after pyretic reaction were observed in rabbits to observe the antipyretic effect of “Qixiang” oral solution. The anti-inflammatory effect of “Qixiang” oral solution was observed by ear auricle swelling test in mice. The hot plate test in mice was used to observe the analgesic effect of “Qixiang” oral liquid. The antibacterial activity of “Qixiang” oral liquid on common respiratory bacteria was observed by in vitro antibacterial experiment. Results: “Qixiang ” oral liquid has antipyretic effect on endotoxin-induced fever model in rabbits, can inhibit xylene-induced ear swelling in mice; can significantly increase the hot plate induced pain threshold in mice; Common respiratory pathogens have some antibacterial effect. Conclusion: “Qiqi” oral solution is an effective anti-respiratory tract infection drugs, with significant antipyretic, anti-inflammatory, analgesic, anti-bacterial effect.