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目的观察急性白血病患者血清LDH及HBDH的含量变化,探讨血清LDH和HBDH与白血病细胞变化的关系及其临床意义。方法采用速率法检测70例白血性白血病患者和24例非白血性白血病患者血清LDH和HB-DH,并与50例健康体检人作对照分析,动态观察了39例急性白血病缓解前后血清LDH和HBDH的变化。结果白血性白血病患者血清LDH和HBDH明显高于非白血性白血病患者和正常对照组(P<0.01),非白血性白血病患者血清LDH和HBDH与正常对照组差异无显著性(P>0.05),而且急性白血病缓解前后血清LDH和HBDH差异有显著性(P<0.01)。结论血清LDH和HBDH可作为急性白血病诊断、疗效、预后的一个辅助指标。
Objective To observe the changes of serum LDH and HBDH in patients with acute leukemia and to explore the relationship between serum LDH, HBDH and leukemia cells and its clinical significance. Methods Serum LDH and HB-DH of 70 patients with leukemia and 24 patients with non-leukemia were detected by the rate method and compared with 50 healthy people. Dynamic changes of serum LDH and HBDH in 39 patients with acute leukemia The change. Results Serum LDH and HBDH in patients with leukemia were significantly higher than those in non-leukemia patients and normal controls (P <0.01). Serum LDH and HBDH levels in non-leukemia patients were not significantly different from those in controls (P> 0.05) And the difference of serum LDH and HBDH before and after the remission of acute leukemia was significant (P <0.01). Conclusions Serum LDH and HBDH can be used as auxiliary indexes for the diagnosis, curative effect and prognosis of acute leukemia.