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已确定狼疮性抗凝因子(LA)是一种抗磷脂抗体,能抑制某些体外凝集试验。检测LA的最敏感的试验是激活的部分凝血酶原时间(APTT)。17～72%的SLE病人以及11-23%的不符合ARA诊断标准的狼疮样综合征病人可检出该因子。血液病、肿瘤、系统性血管炎、感染性疾病中也可检出该因子。
It has been determined that lupus anticoagulant factor (LA) is an antiphospholipid antibody that inhibits certain in vitro agglutination assays. The most sensitive test for detecting LA is activated partial prothrombin time (APTT). This factor can be detected in 17-72% of SLE patients and 11-23% of patients with lupus-like syndrome who do not meet ARA diagnostic criteria. This factor can also be detected in blood diseases, tumors, systemic vasculitis and infectious diseases.