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目的 评价大剂量甲基强的松龙冲击 (HDMP)和静注丙种球蛋白 (IVIG)联合治疗小儿脱髓鞘疾病的疗效。方法 2 5例脱髓鞘疾病的住院患儿随机分为观察组和常规组。观察组 15例应用HDMP和IVIG联合治疗。常规组 10例应用IVIG和地塞米松治疗。结果 观察组 2 4h总有效率 10 0 % ,常规组 2 4h总有效率 5 0 % ;观察组肌力、行走恢复正常所需时间平均 15 89天 ,常规组 2 7 5 6天 ,两组均有显著性差异 (P <0 0 1)。结论 HDMP和IVIG联合治疗小儿脱髓鞘疾病 ,疗效显著 ,值得临床常规应用
Objective To evaluate the efficacy of high-dose methylprednisolone (HDMP) and intravenous gamma globulin (IVIG) in the treatment of demyelinating diseases in children. Methods Twenty-five inpatients with demyelinating disease were randomly divided into observation group and conventional group. The observation group of 15 cases of HDMP and IVIG combined treatment. In the conventional group, 10 cases were treated with IVIG and dexamethasone. Results The total effective rate was 40% in the observation group at 24 hours and 50% at 24 hours in the conventional group. The strength of the observation group was 1589 days after walking back to normal, while 275 days in the conventional group There was a significant difference (P <0.01). Conclusion HDMP and IVIG combined treatment of children with demyelinating disease, a significant effect, it is worth the clinical routine application