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9例生长激素缺乏症(GHD)患儿其垂体对单次生长激素释放激素(GHRH)刺激呈阴性反应(即GH峰值<10ng/ml),当给予GHRH(1—29)-NH_2每日15μg/kg皮下注射连续预充8个月后,除1例GH仍呈阴性反应被诊断为垂体性GHD外,其余8例(89%)在GHRH预充1周至1个月时出现了阳性反应(即GH峰值>10ng/ml),证实了这些患儿病因在于下丘脑。此外其中8例患儿经磁共振影像检查(MRI)其垂体容量在GHRH预充后没有变化。本文结果提示大多数GHD患儿其病变部位在下丘脑,而不在垂体;GHRH预充试验在判断GHD患儿病变部位中有一定的实用价值。
The pituitary gland of nine children with growth hormone deficiency (GHD) was negative for GHRH stimulation (ie, the peak value of GH was less than 10ng / ml). When GHRH (1-29) -NH_2 was given 15μg / kg subcutaneously for 8 months, 8 patients (89%) were positive for GHRH preconditioning for 1 week to 1 month except for one case of GH still negative for pituitary GHD GH peak> 10ng / ml), confirmed that the etiology of these children is the hypothalamus. In addition, 8 cases of children by MRI (MRI) pituitary volume did not change after pre-filling GHRH. Our results suggest that the majority of patients with GHD lesions in the hypothalamus, but not in the pituitary; GHRH pre-charge test in determining the location of GHD children have some practical value.