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目的 观察大鼠和小鼠口服腰痛宁胶囊 (含有马钱子、土鳖虫和全蝎等中药 )的急性毒性作用。方法 以SD和Wistar种大鼠 ,昆明种和BALB/c小鼠为受试对象 ,采用Bliss法测定口服腰痛宁胶囊的LD50 。结果 雄性SD大鼠口服腰痛宁胶囊的LD50 为 6 15 8 95mg/kg ,而雌性大鼠的LD50 为 80 3 85mg/kg;雄性Wistar大鼠口服腰痛宁胶囊的LD50 为 5 80 7 5 7mg/kg,而雌性大鼠的LD50 为 86 1 94mg/kg ;昆明种小鼠口服腰痛宁胶囊的LD50 为 6 4 0 4 4mg/kg ;BALB/C小鼠的LD50 为 4 4 8 34mg/kg。结论 不同性别的大鼠对腰痛宁胶囊的急性毒性反应有非常著性差异 ,SD大鼠雄性LD50 比雌性高 7 6 6倍 ,Wistar大鼠雄性LD50 比雌性高 6 74倍。小鼠LD50 几乎没有性别差异
Objective To observe the acute toxic effects of oral Yaotongning capsules (containing traditional Chinese medicine such as Strychnos subtilis, Eupolyphaga sinensis, and Scorpio sp.) on rats and mice. Methods SD and Wistar rats, Kunming species and BALB/c mice were used as subjects. Bliss was used to determine the LD50 of oral Yaotongning capsule. Results The LD50 of Liaotongning capsules was 6 185 8 95 mg/kg in male SD rats and 80 3 85 mg/kg in female rats. The LD 50 of male Wistar rats was 5 80 7 5 7 mg/kg in oral Yaotongning capsules. The LD50 of the female rats was 86 1 94mg/kg; the LD50 of the oral Kuntongning capsules of the Kunming mice was 6444.4 mg/kg; the LD50 of the BALB/C mice was 4 4 8 34mg/kg. Conclusion There is a significant difference in the acute toxicity of Yaotongning Capsule between rats of different sexes. The male LD50 of SD rats is 696 times higher than that of females. The male LD50 of Wistar rats is 746 times higher than that of females. There is almost no gender difference in mouse LD50