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帕金森病(Parkinson’s disease,PD)是一种常见的神经系统退行性疾病,病理以黑质多巴胺能神经元的丧失和路易体(Lewy body)的形成为特点。大多数 PD 患者无家族史,约15%患者有家族史。研究已发现11个染色体定位以孟德尔遗传方式与 PD 连锁,其中5个呈常染色体显性(autosomaldominant,At))遗传,4个呈常染色体隐性(autosomal
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by the loss of nigral dopaminergic neurons and the formation of Lewy bodies. Most PD patients have no family history and about 15% have a family history. Eleven chromosome loci have been found to be linked to PD by Mendelian inheritance, five of which are autosomal dominant (At) and four are autosomal