Gafdner 等曾在1990年英国医学杂志上报道英国 Sellafield 后处理厂周围儿童白血病增加,认为这是怀孕前诱发的经父传递的生殖细胞突变的结果。因为若干白血病儿童的父亲是该厂职工,在患儿母亲怀胎前6个月曾接受过高达100mSv 的高水平照射,或怀胎前10年内接受较高剂量的照射。 Gafdner et al. reported in the 1990 British Medical Journal the increase in leukemia in children around the Sellafield reprocessing plant in the United Kingdom as a result of pre-pregnancy induced germ cell mutations via the father. Because the father of several children with leukemia is a factory worker, the child received high-level radiation of up to 100 mSv 6 months before the mother’s pregnancy, or received a higher dose of radiation in the first 10 years of pregnancy.