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目的了解聊城地区冠心病患者中单纯餐后高血糖的流行情况,探讨餐后2h血糖(2hPG)水平与冠心痛发病之间的关系,同时对冠心病合并单纯餐后高血糖患者的多种危险因素进行分析,以加深冠心病合并单纯餐后高血糖危险因素的认识,为其及早诊断、干预提供理论依据。方法选择400例冠心病病人和300例正常健康对照者,检测2hPG,血浆Hcy,C-反应蛋白水平,并对比分析。结果冠心病组2hPG明显高于健康组,两组比较差异有统计学意义(P﹤0.05)。冠心病组血浆Hcy水平高于对照组(P﹤0.05),差异有统计学意义,且血浆Hcy与血糖呈正相关。冠心病组C-反应蛋白水平高于对照组(P﹤0.05),有糖代谢异常组高于单纯冠心病组。结论冠心病患者糖代谢异常的发生率较高,餐后2h血糖可能是冠心病的独立危险因素,应加强糖调节受损人群的早期发现及干预,防止或延缓糖尿病大血管并发症的发生、发展,同时,Hcy,CRP与冠心病病发病密切相关,并且糖代谢异常可伴有Hcy、CRP增高。
Objective To investigate the prevalence of simple postprandial hyperglycemia in patients with coronary heart disease in Liaocheng and to explore the relationship between 2h postprandial plasma glucose (2hPG) levels and the incidence of coronary heart disease (CHD). Meanwhile, the risk of coronary heart disease complicated with postprandial hyperglycemia Factor analysis to deepen the understanding of risk factors of postprandial hyperglycemia in patients with coronary heart disease, providing a theoretical basis for its early diagnosis and intervention. Methods 400 cases of coronary heart disease patients and 300 healthy controls were selected to detect 2hPG, plasma Hcy, C-reactive protein levels, and comparative analysis. Results 2hPG in CHD group was significantly higher than that in healthy group, the difference was statistically significant (P <0.05). Plasma homocysteine level in CHD group was higher than that in control group (P <0.05), and the difference was statistically significant. Plasma Hcy was positively correlated with blood glucose level. Coronary heart disease group C-reactive protein levels higher than the control group (P <0.05), abnormal glucose metabolism group than in coronary heart disease group. Conclusions The incidence of abnormal glucose metabolism in patients with coronary heart disease is high. The postprandial blood glucose at 2h may be an independent risk factor for coronary heart disease. Early detection and intervention of impaired glucose regulation should be strengthened to prevent or delay the occurrence of diabetic macrovascular complications. Development, at the same time, Hcy, CRP and coronary heart disease is closely related to the disease, and abnormal glucose metabolism may be associated with Hcy, CRP increased.