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目的:观察在序贯使用甲硝唑及乳酸杆菌的基础上加用知柏地黄丸治疗老年性阴道炎临床疗效。方法:将100例老年性阴道炎的患者随机分成治疗组和对照组各50例,对照组第1周口服甲硝唑片,第2周阴道用乳酸杆菌,治疗组在对照组治疗基础上连续口服知柏地黄丸2周,观察两组对老年性阴道炎患者阴道微环境及生活质量的影响。结果:两组患者的症状评分、阴道p H值、阴道乳酸杆菌数量及清洁度评分均有改善,而治疗组的改善程度较大,维持时间较长,两组比较,差异具有统计学意义(P<0.05);治疗后1个月两组患者生活质量评分均提高,治疗组患者生活质量明显提高,与对照组比较差异具有统计学意义(P<0.05)。结论:知柏地黄丸能有效改善老年性阴道炎患者阴道微环境,提高患者生活质量,且维持时间较长,具有较好的远期疗效,值得在临床推广。
Objective: To observe the clinical efficacy of using Zhibai Dihuang Wan in the treatment of senile vaginitis based on sequential use of metronidazole and lactobacillus. Methods: 100 cases of senile vaginitis were randomly divided into treatment group and control group, 50 cases in each group. The control group received metronidazole tablets in the first week and lactic acid bacteria vagina in the second week. The treatment group continued on the basis of the control group Oral administration of Zhibai Di Huang Wan 2 weeks to observe the two groups of vaginitis in patients with vaginal microenvironment and quality of life. Results: Symptom score, vaginal p H value, number of vaginal lactobacilli and cleanliness score of the two groups were improved, while the improvement of the treatment group was longer and the maintenance time was longer. There was significant difference between the two groups P <0.05). The quality of life scores of both groups increased at one month after treatment, and the quality of life in the treatment group was significantly improved compared with the control group (P <0.05). Conclusion: Zhibai Dihuang Wan can effectively improve the vaginal microenvironment in patients with senile vaginitis, improve the quality of life of patients, and maintain a longer time, with good long-term efficacy, it is worth in the clinical promotion.