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Ｔ与Ｂ细胞对于乙酰胆碱受体α亚单位的反应可出现于大多数重症肌无力患者。我们检测了Ｂ与Ｔ细胞对１０个亚单位（由细胞外、细胞膜间、细胞浆组成的）分子多肽。以免疫酶斑法检测这些多肽的ＩｇＧ抗体分泌细胞，并测定了抗原识别后分泌γ干扰素的辅助Ｔ细胞。结果发现α亚单位全部多肽反应都是免疫原性的。３个以上的多肽同时可在７５％或４８％的重症肌无力患者中起Ｂ或Ｔ细胞抗原决定基作用，但６％或２９％的患者Ｂ或Ｔ细胞对任何多肽无反应。这提示，乙酰胆碱受体其他分子结构可能也具有免疫原性。尚未发现Ｔ与Ｂ细胞免疫优势抗原决定基。在多肽４６－６７反应Ｂ与Ｔ细胞之间呈正相关，但其他多肽的没有发现这种关系。
Response of T and B cells to the acetylcholine receptor alpha subunit can occur in most patients with myasthenia gravis. We examined the B and T cells on the 10 subunits (by the extracellular, intercellular membrane, cytoplasmic components) of the polypeptide. The IgG antibody-secreting cells of these polypeptides were detected by immunoblotting and the helper T cells secreting gamma interferon were assayed after antigen recognition. As a result, it was found that all the polypeptide reactions of the α subunit were immunogenic. More than three polypeptides may act as B or T cell epitopes in 75% or 48% of patients with myasthenia gravis at the same time, but 6% or 29% of patients do not respond to any of the polypeptides. This suggests that other molecular structures of acetylcholine receptors may also be immunogenic. No T and B cell immunodominant epitopes have been found. There was a positive correlation between polypeptide 46-67 response B and T cells, but no such relationship was found with other polypeptides.