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目的为探讨纤溶酶原激活物抑制因子-1(PAI-1)在放射性肾损伤纤维性修复中的作用和意义,揭示其发病的分子病理机制。方法24只雄性健康的Wistar大鼠以30Gy60Coγ线单次双肾局部照射,于照射后4个不同时相点活杀,取肾组织进行常规病理学观察及原位分子杂交,观察PAI-1mRNA表达的变化。结果纤维化的肾组织PAI-1表达较正常对照组增高,与纤维化程度呈正相关。结论PAI-1可能在肾放射性损伤后纤维性修复的发生及发展中起重要的作用。
Objective To investigate the role and significance of plasminogen activator inhibitor-1 (PAI-1) in the pathogenesis of radiation-induced renal injury and to elucidate its molecular pathogenesis. Methods Twenty-four male healthy Wistar rats were irradiated with 30Gy60Coγ ray and irradiated by single double-kidney at 30 Gy 60Coγ ray. The pathological changes of PAI-1 mRNA were observed by routine pathology and in situ hybridization The change. Results The expression of PAI-1 in fibrosis renal tissue was higher than that in normal control group, and positively correlated with the degree of fibrosis. Conclusion PAI-1 may play an important role in the occurrence and development of fibrotic repair after renal radioactive injury.