论文部分内容阅读
目的观察法莫替丁、克拉霉素、左氧氟沙星、果胶铋四联药在治疗幽门螺杆菌(HP)感染的消化性溃疡疗效。方法回顾性分析2009年5月至2012年3月127例HP阳性消化性溃疡患者临床资料,根据治疗方法分为观察组(65例):采用法莫替丁、克拉霉素、左氧氟沙星、果胶铋四联药治疗,对照组(62例):采用以质子泵抑制剂(PPI)为基础的三联药治疗。结果观察组比对照组症状改善时间早,2组比较差异有统计学意义(P<0.05),但2组在溃疡愈合率、不良反应及HP转阴情况比较差异无统计学意义(P>0.05)。结论以法莫替丁、克拉霉素、左氧氟沙星和果胶铋四联药在治疗HP阳性消化性溃疡中具有症状改善时间早的优点。
Objective To observe the efficacy of famotidine, clarithromycin, levofloxacin and pectin bismuth in the treatment of peptic ulcer caused by Helicobacter pylori infection. Methods The clinical data of 127 patients with HP-positive peptic ulcer from May 2009 to March 2012 were retrospectively analyzed. According to the treatment method, they were divided into observation group (65 cases): famotidine, clarithromycin, levofloxacin, pectin Bismuth quadruple drug treatment, control group (62 cases): the use of proton pump inhibitor (PPI) -based triple therapy. Results The symptom improvement time of observation group was earlier than that of control group, there was significant difference between two groups (P <0.05), but there was no significant difference between the two groups in the healing rate of ulcer, adverse reaction and HP negative conversion (P> 0.05 ). Conclusion Famotidine, clarithromycin, levofloxacin and pectin bismuth quadruple drug in the treatment of HP-positive peptic ulcer with the advantages of early improvement of symptoms.