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目的探讨奥扎格雷与甲钴胺片联合治疗对糖尿病周围神经病变(DPN)的临床疗效。方法将86例DPN患者随机分为治疗组48例,采用奥扎格雷治疗,同时甲钴胺肌内注射;对照组38例,单纯用甲钴胺肌内注射。两组均以4周为1疗程,治疗1疗程。观察临床疗效及治疗前后神经传导速度(NCV)的变化。结果总有效率,治疗组明显高于对照组,差异有显著性(P<0.05)。NCV改善情况,治疗组明显优于对照组(P<0.01)。结论奥扎格雷与甲钴胺联合应用能够减轻DPN患者的临床症状,并改善其神经传导速度,提高临床疗效。
Objective To investigate the clinical efficacy of ozagrel and mecobalamin in the treatment of diabetic peripheral neuropathy (DPN). Methods Eighty-six patients with DPN were randomly divided into treatment group (n = 48) treated with ozagrel and intramuscular injection of methylcobalamin. Control group (n = 38) was given intramuscular injection of methylcobalamin alone. Both groups were 4 weeks for a course of treatment for 1 course of treatment. To observe the clinical efficacy and changes in nerve conduction velocity (NCV) before and after treatment. The total effective rate, the treatment group was significantly higher than the control group, the difference was significant (P <0.05). NCV improvement, the treatment group was significantly better than the control group (P <0.01). Conclusion Ozagrel combined with mecobalamin can reduce the clinical symptoms of DPN patients and improve the nerve conduction velocity and improve clinical efficacy.