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目的 比较盐酸格拉司琼和进口同类药物 (商品名 :康泉 )的止吐疗效。方法 病例采取随机自身交叉对照和部分开放的方法进行。符合标准的患者随机 (信封法 )进入自身对照或开放组 ,观察临床反应和实验室指标 ,评价制剂的安全性和有效性。结果 两药止吐疗效相似。国产盐酸格拉司琼对呕吐、恶心、恶心呕吐的总有效率分别为 80 5 8%、79 6 9%、75 5 4% ;康泉分别为 86 3 %、75 6 4%、79 49%。两者副作用均小。结论 盐酸格拉司琼为高效低毒、安全可靠的止吐药。
Objective To compare the antiemetic efficacy of granisetron hydrochloride and similar imported drugs (trade name Kangquan). Methods Patients were randomized to cross-control and partially open method. Patients who met the criteria randomly (envelope method) into their own control or open group, observe the clinical response and laboratory indicators to evaluate the safety and effectiveness of the preparation. The results of two drugs antiemetic effect similar. The total effective rates of domestic granisetron hydrochloride on vomiting, nausea and nausea and vomiting were 80.58%, 79.69% and 75.54%, respectively. Kangquan was 86.3%, 75.64% and 79.49% respectively. Both side effects are small. Conclusion Granisetron hydrochloride is an effective and low toxicity, safe and reliable antiemetic.