论文部分内容阅读
目的：研究p27蛋白在肺鳞状细胞癌中的表达，并探讨其与预后及临床病理学特征之间的关系。方法：应用免疫组化法检测p27蛋白在73例肺鳞状细胞癌中的表达水平，并用log－rank检验检测p27表达与生存时间的关系。Cox回归模型作单因素、多因素预后分析。结果：p27在肺鳞状细胞癌中高表达率为39．8％（29／73），低表达率为60．2％（44／73），p27的表达与肺鳞状细胞癌患者术后生存期及肿瘤分化程度显著性正相关，并可作为一个独立的判断预后的指标。但其表达水平与肿瘤大小、淋巴结转移、TNM分期均无关。结论：p27表达指数可作为判断肺鳞状细胞癌预后的重要指标。
Objective: To investigate the expression of p27 protein in lung squamous cell carcinoma and to explore its relationship with prognosis and clinicopathological features. Methods: The expression of p27 protein in 73 cases of lung squamous cell carcinoma was detected by immunohistochemistry, and the relationship between p27 expression and survival time was tested by log-rank test. Cox regression model for univariate, multivariate prognostic analysis. Results: The positive rate of p27 expression in lung squamous cell carcinoma was 39.8% (29/73) and the low expression rate was 60.2% (44/73). The expression of p27 correlated with the postoperative survival of patients with squamous cell carcinoma of the lung Stage and tumor differentiation was significantly positive correlation, and can be used as an independent prognostic indicators. However, its expression level had no relation with tumor size, lymph node metastasis and TNM staging. Conclusion: The p27 expression index can be used as an important index to judge the prognosis of lung squamous cell carcinoma.