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目的:分析六安市2008~2011年度围生儿出生缺陷的发生情况及相关因素。方法:对2008~2011年六安市7家出生缺陷监测医院上报的34 478例围生儿中发现的309例出生缺陷资料进行回顾性分析。结果:2008~2011年六安市围生儿出生缺陷发生率为89.62/万,低于全国和安徽省平均水平,且呈逐年下降趋势;出生缺陷顺位近4年排序改变较大,神经管畸形和脑积水的发生率明显下降。结论:加强出生缺陷的三级预防工作,可有效降低出生缺陷发生率和围产儿死亡率。“,”Objective:To analyze the occurrence and related factors of birth defects in perinatal infants in Liuan city from 2008 to 2011.Methods:The data of 309 perinatal infants with birth defects among 34 478 perinatal infants reported by seven monitoring hospitals of birth defects in Liuan city from 2008 to 2011 were analyzed retrospectively.Results:The incidence rate of birth defects among perinatal infants in Liuan city from 2008 to 2011 was 89.62/10 000,which was lower than national level and mean level in Anhui province,and it showed a decreasing trend year by year;the rank of birth defects in recent four years changed significantly,the incidence rates of neural tube defect and hydrocephalus decreased significantly.Conclusion:Strengthening tertiary prevention of birth defects may effectively reduce incidence rates of birth defects and perinatal mortality.