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研究牛磺酸对脂肪代谢的影响及其作用机制。方法：配制致高胆固醇血症饲料。将面粉４５％，淀粉１２％，玉米９％，麸皮７％，酵母４％，鱼粉４％，豆粕４％，骨粉１％，鱼肝油１％，盐１％，猪油１２％均匀搅拌后；再向每１００ｇ混合饲料中加１ｇ胆固醇及０．２５ｇ胆酸钠。将７５只Ｗｉｓｔａｒ雌性大鼠随机分为５组，每组１５只，组内设三个重复，每个重复５只大鼠。第１、２、３组饲喂致高胆固醇血症饲料并分别添加１％、３％、５％的牛磺酸，第４组为饲喂致高胆固醇血症饲料的对照组，第５组为饲喂基础饲料的对照组，进行五周的饲养试验后，杀鼠取样。用酶比色法测定血清中的胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）含量，并推导动脉粥样硬化指数（ＡＩ）；用索氏浸提法测定肝中脂肪含量；用高效液相色谱法测定血清中牛磺酸含量，用双抗体放射免疫法测定血清甲状腺激素（Ｔ３，Ｔ４）及肝组织Ｔ４５－脱单碘酶（Ｔ４５－ＤＩ）活性。结果：在实验五周末，喂高脂高胆固醇饲料的大鼠血清中ＴＣ、ＨＤＬ－Ｃ水平、ＡＩ值、ＴＧ水平、肝脂肪含量显著高于喂普通饲料的大鼠。喂高脂饲料的大鼠添加１％的牛磺酸，提高了血清中ＨＤＬ－Ｃ水平。肝中Ｔ４５－ＤＩ活性、?
Study of taurine on fat metabolism and its mechanism of action. Methods: Preparation of hypercholesterolemia feed. Flour 45%, starch 12%, corn 9%, bran 7%, yeast 4%, fish meal 4%, soybean meal 4%, bone meal 1%, cod liver oil 1%, salt 1%, lard 12% Add 1 g of cholesterol and 0.25 g of sodium cholate to each 100 g of mixed feed. Seventy five Wistar female rats were randomly divided into five groups of 15, with three replicates in each group and five rats each. Groups 1, 2 and 3 fed hypercholesterolemic diet supplemented with 1%, 3% and 5% taurine, respectively. Group 4 served as control group fed hypercholesterolemic diet. Group 5 For the control group fed the basal diet, after five weeks of feeding trials, the mice were sampled. Serum levels of cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) were determined by enzyme-linked immunosorbent assay (ELISA), and atherosclerosis index (AI) The content of fat in the liver was measured. The content of taurine in the serum was determined by high performance liquid chromatography. Serum thyroid hormones (T3 and T4) and T45-deiodinase (T45-DI )active. Results: At the end of the fifth week, the levels of TC, HDL-C, AI, TG and hepatic fat in the serum of rats fed high-fat and high-cholesterol diet were significantly higher than those in normal rats. Rats fed high-fat diets had 1% taurine supplementation, raising serum HDL-C levels. Liver T45-DI activity,?