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β-hCG的放射免疫测定是目前滋养叶疾病诊断和随访的最好指标。血清中hCG与脑脊液(CSF)中的比例可用于鉴定脑转移。 SP 1由滋养层产生,且发现于滋养叶疾病患者的血清中。血清β-hCG通常SP1高,极少病人β-hCG测不到时能测出SP1(Searle等,1968)。Soma等(1981)测定5例滋养叶疾病病人CSF中SP1的浓度发现SP1仅出现在脑转移的病人中,指出在处理此等病人时SP1可作为另一肿瘤标记。本文测定许多滋养叶疾病患者SP1在血清和CSF中的水平以查明SP1水平和与病人预后的关系,是否有
Radioimmunoassay of β-hCG is the best indicator of trophoblastic disease diagnosis and follow-up. The ratio of serum hCG to CSF (CSF) can be used to identify brain metastases. SP 1 is produced by the trophoblast and is found in the serum of trophoblast disease patients. Serum β-hCG is usually high in SP1, and SP1 is undetectable in very few patients with beta-hCG (Searle et al., 1968). Soma et al. (1981) measured the concentration of SP1 in the CSF of 5 patients with trophoblastic disorders. SP1 was found only in patients with brain metastases, indicating that SP1 may serve as another tumor marker in the treatment of these patients. This article measures SP1 levels in serum and CSF in many trophoblastic disorders to ascertain the association between the level of SP1 and the patient’s prognosis. Is there any