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目的分析早期胃癌的临床病理特征与预后之间的关系。方法回顾性分析1994年1月至2005年10月间,在我院实施D2根治术且资料完整的255例早期胃癌患者的临床资料,采用Kaplan-Meier法进行生存分析,Logrank检验进行统计学比较,Cox比例风险模型进行多因素分析。结果 255例患者的5年生存率为91.4%。单因素分析显示,肿瘤浸润深度、脉管瘤栓和区域淋巴结转移与患者术后生存率有关;而性别、年龄、肿瘤大小、肿瘤位置、大体类型、分化程度与术后生存率无关。多因素分析显示,区域淋巴结转移是影响预后的独立危险因素。结论伴有区域淋巴结转移的早期胃癌患者预后较差,标准胃癌根治性手术后应接受综合治疗并严密随访。
Objective To analyze the relationship between clinicopathological characteristics and prognosis of early gastric cancer. Methods A retrospective analysis of clinical data of 255 patients with early gastric cancer who underwent D2 radical mastectomy in our hospital from January 1994 to October 2005 was performed. Survival analysis was performed by Kaplan-Meier method and compared with Logrank test , Cox proportional hazards model for multivariate analysis. Results The 5-year survival rate of 255 patients was 91.4%. Univariate analysis showed that the depth of tumor invasion, tumor thrombus and regional lymph node metastasis were related to the postoperative survival rate of patients, while gender, age, tumor size, tumor location, general type, differentiation degree had no relation with postoperative survival rate. Multivariate analysis showed that regional lymph node metastasis was an independent risk factor for prognosis. Conclusion The prognosis of patients with early stage gastric cancer with regional lymph node metastasis is poor. Standard gastric cancer should be treated comprehensively and closely followed up after radical surgery.