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目的 :探讨充血性心力衰竭 (CHF)患者肾素、血管紧张素和醛固酮活性的变化。方法 :采用放免法测定收缩压 (pSB) <13.33kPa的CHF患者 (A组 ,2 8例 ) ,pSB>13.33kPa的CHF患者 (B组 ,32例 )及健康人 (对照组 ,2 5例 )血浆肾素活性 (PRA)、血管紧张素Ⅱ (AngⅡ )及醛固酮 (ALD)水平。结果 :A组及B组血浆PRA、AngⅡ和ALD均明显高于对照组 ,差异有统计学意义 (P <0 .0 5或 0 .0 1) ;A组血清钠、pSB及脉压 /pSB显著低于对照组 ,差异有统计学意义 (P <0 .0 5或 0 .0 1) ;A组血浆PAR、AngⅡ和ALD高于B组 ,差异有统计学意义 (P <0 .0 5或 0 .0 1) ;A组血清钠、pSB及脉压 /pSP显著低于B组 ,差异有统计学意义 (P <0 .0 5或 0 .0 1) ;CHF患者脉压 /pSB与血浆AngⅡ及ALD呈负相关 (r=- 0 .4 6 2 ,P <0 .0 1;r=- 0 .4 4 3,P <0 .0 1)。结论 :CHF患者体内肾素 -血管紧张素 -醛固酮系统活性增高 ,且pSB<13.33kPa者高于pSB>13.33kPa者
Objective: To investigate the changes of renin, angiotensin and aldosterone in patients with congestive heart failure (CHF). Methods: The CHF patients (group A, 28 cases) with systolic blood pressure (pSB) <13.33 kPa and the patients with CHF (group B, 32 cases) and healthy subjects (control group, 25 cases ) Plasma renin activity (PRA), angiotensin Ⅱ (Ang Ⅱ) and aldosterone (ALD) levels. Results: The plasma levels of PRA, Ang Ⅱ and ALD in group A and group B were significantly higher than those in control group (P <0.05 or 0.01). The serum sodium, pSB and pulse pressure / pSB in group A (P <0.05 or 0.01). The plasma levels of PAR, AngⅡ and ALD in group A were significantly higher than those in group B (P <0.05), the difference was statistically significant Or 0.01). The serum sodium, pSB and pulse pressure / pSP in group A were significantly lower than those in group B (P <0.05 or 0.01) There was a negative correlation between plasma Ang Ⅱ and ALD (r = - 0.642, P <0.01; r = - 0.434, P <0.01). CONCLUSIONS: The activity of renin-angiotensin-aldosterone system in patients with CHF is higher than that of patients with pSB <13.33 kPa and pSB> 13.33 kPa