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黄连素为毛莨科植物黄连根茎中提取的一种异喹啉生物碱,可由黄连、黄柏等植物提取,也可人工合成。既往多认为口服后不易吸收,因其对痢疾杆菌、大肠杆菌、金葡菌等引起的肠道感染、眼结膜炎、化脓性中耳炎等有效,临床主要用于肠道感染的治疗。随着近年来研究的深入,发现黄连素除用于肠道感染外,还具有治疗心律失常、糖尿病、消化性溃疡、高脂血症等的作用。1口服吸收的问题 研究表明,人口服黄连素后能被吸收,且能达到
Berberine is an isoquinoline alkaloid extracted from the rhizome of Cinnamomum berberii, and it can be extracted from plants such as Coptis chinensis, Phellodendron amurense, or artificially synthesized. In the past, it was thought that it was not easy to absorb after oral administration because it was effective against intestinal infections such as Shigella, E. coli, and Staphylococcus aureus, conjunctivitis of the eye, and suppurative otitis media, and it was mainly used for the treatment of intestinal infections. With the deepening of research in recent years, it has been found that berberine has the effect of treating arrhythmia, diabetes, peptic ulcer, and hyperlipidemia in addition to intestinal infection. 1 The issue of oral absorption Studies have shown that humans can be absorbed after oral administration of berberine and can achieve