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目的:通过临床随访观察,确定用立体定向分次放射治疗(Fractionted Stereotactic Radiotherapy,FSRT)体部肿瘤的近期疗效。对象与方法:96例体部肿瘤患者,其中38例肺癌、12例肝癌、11例胰腺癌、6例纵隔恶性肿瘤、6例食管癌、5例胃癌、5例胆管癌、6例直肠癌、3例宫颈癌和卵巢癌、4例椎骨转移瘤,继确诊和/或手术后,均经x线立体定向分次放射治疗。全部病例中67例(70%)经术前经皮穿刺针吸活组织检查或术后病理组织学检查证实,其余病例由临床、CT和/或磁共振等影像资料证实。用体箱、负压袋固定患者后CT扫描定位,X线立体定向放射治疗计划系统设计并优化治疗计划,加速器旋转照射。部分病人结合常规放射治疗。结果:X线立体定向放射治疗后1~3周内,90例(近94%)表现出临床症状明显改善,而且在此期间未发现1例严重并发症或死亡。肺癌患者随访CT检查32例,其中29例于FSRT后1~6个月肿瘤消失,2例肿瘤体积缩小50%以上,只有1例肿瘤大小无变化,有效率近97%。FSRT对其他肿瘤也有明显疗效,不仅可使原发癌灶缩小或消失,而且可使有癌转移的淋巴结消失。结论:FSRT是一种安全、无痛苦的、且能保持器官原有形态、结构及功能的治疗体部肿瘤的方法,它不仅适合于早期肿瘤患者,而且尤其适合于那些年老体弱,不能耐受手术的或术后残
OBJECTIVE: To determine the short-term effect of the treatment of solid tumors with Fractionted Stereotactic Radiotherapy (FSRT) through clinical follow-up. PARTICIPANTS AND METHODS: Ninety-six patients with body tumors, including 38 lung cancer, 12 liver cancer, 11 pancreatic cancer, 6 mediastinal cancer, 6 esophageal cancer, 5 gastric cancer, 5 cholangiocarcinoma, 6 rectal cancer, 3 cases of cervical cancer and ovarian cancer, 4 cases of vertebral metastases, followed by diagnosis and / or surgery, were x-ray stereotactic fractionated radiotherapy. Sixty-seven cases (70%) were confirmed by percutaneous needle biopsy or postoperative histopathological examination in all cases. The remaining cases were confirmed by clinical, CT and / or magnetic resonance imaging data. With the box, negative pressure bag fixation of patients after CT scan positioning, X-ray stereotactic radiotherapy planning system design and optimization of treatment plan, accelerator rotation irradiation. Some patients with conventional radiation therapy. RESULTS: Within 1 to 3 weeks after X-ray stereotactic radiotherapy, 90 (nearly 94%) patients showed marked improvement in clinical symptoms and no serious complication or death was found during this period. Thirty-two cases of lung cancer were followed up. Among them, 29 cases disappeared 1 to 6 months after FSRT. The volume of tumor in 2 cases was reduced by 50% or more. Only 1 case had no change in tumor size and the effective rate was nearly 97%. FSRT also has significant effect on other tumors, not only can reduce or disappear the primary foci, but also to have lymph node metastasis disappeared. Conclusion: FSRT is a safe and painless method to treat the tumor in the body, which can maintain the original morphology, structure and function of the organ. It is not only suitable for patients with early-stage tumors, but also suitable for those who are frail, Resistant to surgery or postoperative residual