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疱疹样皮炎(DH)与肠病之间的关系早在1966年已被Marks等首先证明,随即发现肠病是对谷胶过敏。但是对于DH中谷胶过敏性肠病(GSE)的发病率与意义仍有争论,较早的观点认为DH病人有二组:一组约2/3的病人有GSE,仅这些病人像成人小肠吸收不良症(Adult coeliac disease,ACD)一样,HL—A_8的发生率增加;而另一组HL—A_8发生率正常、无肠病。目前的观点相信所有的DH病人都有GSE,而那些较早报道的仅2/3的病人有GSE是由于诊断的标准不适当所造成的。对于DH中皮肤和肠病之间的关系也有二种不同的观点:第一种观点认为这样关系是直接的,皮肤和肠道损害都与谷胶有关;第二种观点认为上述关系是间接的,皮肤损害与谷胶无关。
The relationship between dermatitis herpetiformis (DH) and bowel disease was first proven by Marks et al. In 1966 and was subsequently found to be an allergy to gluten. However, there is still debate about the incidence and significance of glutenin-sensitive enteropathy (GSE) in DH. Earlier, it was thought that there are two groups of patients with DH: about two-thirds of patients in a group have GSE, and only these patients, like adult small intestine, Like adult coeliac disease (ACD), the incidence of HL-A_8 increased; while the other group of normal incidence of HL-A_8, no bowel disease. The current view is that all patients with DH have GSE, whereas those reported earlier in only two-thirds of patients have GSE due to inappropriate diagnostic criteria. There are two different perspectives on the relationship between skin and bowel disease in DH: the first is that the relationship is direct, the damage to the skin and gut are related to gluten, and the second is that the above relationship is indirect Skin damage has nothing to do with gluten.