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目的探讨乳腺原发性淋巴瘤的临床病理特点、组织学类型、鉴别诊断及预后。方法收集10例乳腺原发性淋巴瘤的临床病理资料,对其进行HE染色及免疫组化标记。结果 10例乳腺原发性淋巴瘤中9例为女性,发病年龄26～70岁,中位年龄51岁;1例男性,63岁。左乳3例,右乳6例,双乳1例;8例为临床ⅠE期,2例为临床ⅡE期。7例为弥漫性大B细胞性淋巴瘤(DLBCL);2例为黏膜相关淋巴组织结外边缘区B细胞性淋巴瘤(MALT);1例为外周T细胞性淋巴瘤。10例白细胞共同抗原(LCA)均(+);角蛋白、上皮膜抗原均为(-);B细胞标记9例CD20(+),T细胞标记1例CD3(+)。结论乳腺原发性淋巴瘤少见,术前诊断比较困难,准确的病理诊断及组织学分型对规范治疗及预后有重要作用。
Objective To investigate the clinicopathological features, histological types, differential diagnosis and prognosis of primary breast lymphoma. Methods Clinicopathological data of 10 cases of primary breast lymphoma were collected and stained with HE and labeled with immunohistochemistry. Results Of the 10 cases of primary breast lymphoma, 9 were female. The age of onset was 26-70 years. The median age was 51 years. One male was 63 years old. 3 cases of left breast, 6 cases of right breast and 1 case of breast milk, 8 cases were clinical stage IE and 2 cases were clinical stage IIE. 7 cases were diffuse large B-cell lymphoma (DLBCL), 2 cases were marginal zone B-cell lymphoma (MALT) of mucosa-associated lymphoid tissue and 1 case was peripheral T-cell lymphoma. 10 cases of leukocyte common antigen (LCA) were (+); keratin, epithelial membrane antigen were (-); B cells labeled 9 cases of CD20 (+), T cells labeled 1 case of CD3 (+). Conclusions Breast primary lymphoma is rare and preoperative diagnosis is difficult. Accurate pathological diagnosis and histological classification play an important role in standardizing treatment and prognosis.