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目的探讨超敏C-反应蛋白与血脂联合检测在冠心病的发生、发展中的作用,为临床治疗及预后判断提供实验室依据。方法测定冠心病患者血清hs-CRP、总胆固醇(TC)、三酰甘油(TG)水平,分析其变化规律。结果 CHD组与对照组比较,CHD组hs-CRP、TC、TG水平明显高于对照组,差异有统计学意义(P<0.05)。CHD组内比较,SAP组、UAP组、AMI组TC、TG间差异无统计学意义(P>0.05),3组之间hs-CRP水平差异有统计学意义(P<0.05)。结论本研究认为hs-CRP作为正在进行的炎症标记和较敏感的心血管病危险预测因子,其重要性独立于某些传统危险因子(肥胖、高血压、血脂异常、吸烟等),若联合检测超敏C-反应蛋白与血脂对冠心病的早期诊断,判断CHD的严重程度,预测AMI的发生以及CHD的治疗和预后判断在临床实践中具有重大的意义。
Objective To investigate the role of combined detection of hypersensitive C-reactive protein and lipids in the occurrence and development of coronary heart disease (CHD) and to provide a laboratory basis for clinical treatment and prognostic judgment. Methods The levels of serum hs-CRP, total cholesterol (TC) and triglyceride (TG) in patients with coronary heart disease were measured and their changes were analyzed. Results Compared with the control group, the levels of hs-CRP, TC and TG in CHD group were significantly higher than those in control group (P <0.05). There was no significant difference between TC, TG in SAP group, UAP group and AMI group (P> 0.05). There was significant difference in hs-CRP level between the three groups (P <0.05). Conclusions This study suggests that hs-CRP, as an ongoing marker of inflammatory markers and a predisposing predictor of cardiovascular disease, is independent of some of the traditional risk factors (obesity, hypertension, dyslipidemia, smoking, etc.) Hypersensitivity C-reactive protein and lipid on the early diagnosis of coronary heart disease, to determine the severity of CHD, predict the occurrence of AMI and CHD treatment and prognostic judgment in clinical practice is of great significance.