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目的:探讨FHIT、BRCA2及MLH1在河南食管癌高发区家族史阳、阴性食管癌患者癌组织中的表达变化,及其与食管癌遗传易感性之间的关系。方法:采用ABC法检测河南省食管癌高发区林州市74例食管癌患者(其中33例家族史阳性,41例家族史阴性)手术切除标本癌组织FHIT、BRCA2及MLH1蛋白表达情况。结果:FHIT[56%(18/33)]、BRCA2[67%(22/33)]和MLH1[73%(24/33)]在家族史阳性食管癌患者癌组织中阴性表达率,显著高于家族史阴性食管癌患者[27%(11/41)、37%(15/44)和27%(16/41)],P值均<0·05。结论:FHIT、BRCA2和MLH1蛋白可能是影响食管癌遗传易感性的重要分子事件之一。
Objective: To investigate the expression changes of FHIT, BRCA2 and MLH1 in cancerous tissues of esophageal cancer patients with positive family history and high esophageal cancer in Henan province and their relationship with genetic susceptibility to esophageal cancer. Methods: The ABC method was used to detect the protein expression of FHIT, BRCA2 and MLH1 in 74 cases of esophageal cancer patients (including 33 positive family history and 41 negative family history) of esophageal cancer in Linzhou, a high incidence area of esophageal cancer in Henan Province. Results: The negative rates of FHIT (56%, 18/33), BRCA2 (67%, 22/33) and MLH1 (73%, 24/33) were significantly higher in patients with family history of esophageal cancer Family history of patients with negative esophageal cancer [27% (11/41), 37% (15/44) and 27% (16/41)], P values were <0.05. Conclusion: FHIT, BRCA2 and MLH1 proteins may be one of the important molecular events that affect the genetic predisposition of esophageal cancer.