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【目的】对比研究曲美他嗪与红景天对进入高原新兵的抗高原反应的作用。【方法】选120名拟入高原(海拔3 280 m)服役新兵,随机分为曲美他嗪(T)组和红景天(R)组各60名。分别对其进入高原前未用药和用药并进入高原后7 d的高原反应性评分、心功能、肺功能进行评估,检测动脉血气及静脉血氧化-应激指标。【结果】与进入高原前比较,进入高原7 d后战士的心肺功能、血气及血清氧化-应激指标均有相应的改变(P<0.05);进入高原7 d后与R组比较,T组的收缩压(SBP)和心功能指数(CFI)较红R组低[SBP(117.20±11.26)mm Hg vs.(124.79±11.10)mm Hg,1 mm Hg=0.1333 k Pa,P<0.05][CFI(12.74±2.44)vs.(15.33±3.17),P<0.05];而氧化-应激指标CAT、NO、H2O2、LA、SOD在两个受试组有明显统计学差异(P<0.05)。高原反应性评分两组间无差异。【结论】曲美他嗪与红景天抗急性高原反应能力相似,但其作用有所不同,曲美他嗪更利于改善心功能,而红景天则更利于抗氧化-应激反应。
【Objective】 To compare the effect of trimetazidine and Rhodiola rosea on the anti-altitude sickness of recruits entering the plateau. 【Method】 120 newly recruited soldiers who were enrolled into the plateau (3 280 m above sea level) were randomly divided into trimetazidine (T) group and Rhodiola (R) group. The plateau reactivity score, heart function and pulmonary function were evaluated on the 7th day after they entered the plateaus before entering the plateaus and entering the plateau. The arterial blood gases and venous blood oxygen-stress indexes were measured. 【Result】 Compared with the control before entering the plateau, the cardiorespiratory function, blood gas and serum oxidant-stress index of the soldiers on the 7th day after entering the plateau all changed accordingly (P <0.05). Compared with the R group, Systolic blood pressure (SBP) and cardiac function index (CFI) were significantly lower than those of the red group [SBP (117.20 ± 11.26) mm Hg vs. (124.79 ± 11.10) mm Hg and 1 mm Hg = 0.1333 kPa, respectively] CFI (12.74 ± 2.44) vs. (15.33 ± 3.17), P <0.05]. The levels of CAT, NO, H2O2, LA and SOD were significantly different between the two groups (P <0.05) . Alkaline reactivity score was no difference between the two groups. 【Conclusion】 Trimetazidine and Rhodiola rosea have similar anti-acute altitude response, but their effects are different. Trimetazidine is more effective in improving cardiac function, while Rhodiola is more beneficial to anti-oxidative-stress response.