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目的 探讨肝细胞肝癌表观扩散系数(ADC)值与Ki-67指数之间的关联性,更全面地了解肝癌的恶性程度、增殖活性.方法 经手术病理证实的59例肝癌患者,术前在b值为600的DWI图像上测量ADC值,术后S-P免疫组织化学染色Ki-67,两者数据再通过Speaman行相关性分析.结果 59例肝癌患者分成低分化、中分化和高分化组.高分化组肝癌平均ADC值为(1.173±0.076)×10-3 mm2/s,中分化组平均ADC值(1.036±0.079)×10-3mm2/s,低分化组平均ADC值为(0.824±0.145)×10-3mm2/s.高分化组Ki-67平均值为11.600％;中分化组平均值为29.808％;低分化组平均值为59.722％.通过Spearman等级相关系数分析得出肝癌Ki-67与ADC值呈负相关(r=-0.80492,P＜0.001).结论 肝癌ADC值与Ki-67指标呈负相关,能够在术前为了解肝癌生物学特性提供影像学依据,并为临床提供更好的治疗方案.“,”Objective This study intends to explore the correlation between the apparent diffusion coefficient (ADC)value and the Ki-67 index,which can give a more comprehensive understanding of the malignant degree and the proliferation activity of liver cancer.Methods 59 cases of hepatocellular carcinoma were confirmed by operation and pathology.Before operation,we measured the ADC value of the lesion on the B value of 600 ADC.After the operation,the SP immunohistochemical staining Ki-67 was used to analyze the correlation between and Spearman.Results 59 patients with liver cancer were divided into low differentiation,middle differentiation and high differentiation group.The average ADC in high differentiation group was 1.173 ±0.076(× 10-3mm2/s);in middle differentiation group was 036 ±0.079(× 10-3mm2/s);in low differentiation group was 0.824 ± 0.145 (× 10-3 mm2/s).The Ki-67 in high differentiation group the average is 11.600％;in middle differentiation group the average is 29.808;in low differentiation group the average is 59.722％.The correlation coefficient of Spearman rank correlation coefficient showed that the Ki-67 and ADC value were negatively correlated(r =-0.80492,P ＜ 0.001).Conclusion The ADC value of liver cancer was negatively correlated with Ki-67 index,which could provide imaging evidence for the biological characteristics of HCC before operation and provide a better vtreatment.