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目的:探索序贯结肠透析联合中药对早中期慢性肾功能衰竭患者的临床疗效。方法:将我院120例确诊的慢性肾衰竭患者随机分成为口服药物组、中药保留灌肠组、序贯结肠透析联合中药治疗组,治疗12周后观察Scr、BUN、UA、Alb、Hb、PTH指标的变化。结果:口服组治疗后Scr、BUN、UA下降不明显,血A1b、Hb、PTH无明显变化;中药保留灌肠组Scr治疗后明显下降,P<0.01,BUN、UA下降不明显,BUN、UA与口服组比较无明显差异,但对降低Scr的作用优于口服组,血Alb、Hb、PTH无明显变化;序贯结肠透析联合中药治疗组治疗后Scr、BUN明显下降,P<0.01,序贯结肠透析联合中药治疗组对降低Scr、BUN的作用均优于前两组,P<0.01,血Alb、Hb治疗后明显升高,P<0.01,对营养状况的改善均优于前两组P<0.01,PTH无明显变化。结论:序贯结肠透析联合中药对早中期慢性肾功能衰竭患者的临床疗效显著。
Objective: To explore the clinical efficacy of sequential colon dialysis combined with traditional Chinese medicine on patients with chronic renal failure in early and mid-term. Methods: 120 patients with chronic renal failure diagnosed in our hospital were randomly divided into oral drug group, traditional Chinese medicine retention enema group and sequential colon dialysis combined with traditional Chinese medicine treatment group. After 12 weeks of treatment, Scr, BUN, UA, Alb, Hb, PTH Changes in indicators. Results: The Scr, BUN and UA did not decrease obviously in the oral group, but there was no significant change in blood A1b, Hb and PTH after oral administration. The Scr in the retention enema of the traditional Chinese medicine group decreased significantly after treatment with P <0.01, but the BUN and UA did not decrease obviously. Oral administration group had no significant difference, but the effect of reducing Scr was better than oral group, blood Alb, Hb, PTH no significant change; sequential colon dialysis combined with traditional Chinese medicine treatment group Scr, BUN decreased significantly, P <0.01, sequential Colonic dialysis combined with traditional Chinese medicine treatment group to reduce the role of Scr, BUN are better than the former two groups, P <0.01, blood Alb, Hb significantly increased after treatment, P <0.01, the improvement of nutritional status are better than the previous two groups P <0.01, PTH no significant change. Conclusion: Sequential colon dialysis combined with traditional Chinese medicine has a significant clinical effect on patients with chronic renal failure in early and middle stages.