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目的 探讨急性期脑梗死患者脂蛋白 (α) [Lp(α) ]和氧化低密度脂蛋白 (OXLDL)的水平及临床意义。方法 随机选择 36例急性期脑梗死患者测定血清Lp(α)和OXLDL水平 ,30例健康人作为对照组。结果 脑梗死急性期血清Lp(α)和OXLDL水平显著高于对照组 (P <0 .0 1) ;大面积脑梗死患者血清Lp(α)和OXLDL水平显著高于小面积脑梗死 (P <0 .0 1) ;Lp(α)和OXLDL间呈正相关 (P <0 .0 1)。结论 脑梗死急性期血清Lp(α)和OXLDL水平增高 ;Lp(α)和OXLDL水平与脑梗死面积有关。脑梗死患者应用抗氧化剂治疗是必要的。
Objective To investigate the levels and clinical significance of lipoprotein (α) [Lp (α)] and oxidized low density lipoprotein (OXLDL) in patients with acute cerebral infarction. Methods Serum Lp (α) and OXLDL levels were measured in 36 patients with acute cerebral infarction and 30 healthy individuals as control group. Results Serum levels of Lp (α) and OXLDL in the acute stage of cerebral infarction were significantly higher than those in the control group (P <0.01). The levels of serum Lp (α) and OXLDL in patients with severe cerebral infarction were significantly higher than those in small area infarction (P < 0 .0 1). There was a positive correlation between Lp (α) and OXLDL (P <0.01). Conclusions Serum levels of Lp (α) and OXLDL are increased in the acute stage of cerebral infarction. The levels of Lp (α) and OXLDL are related to the infarct size. Anti-oxidant therapy is necessary for patients with cerebral infarction.