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AIM: To compare the efficacy and safety of five days apostrophe therapy of mebendazole (MBZ) versus quina- crine (QC) on human giardiasis in children. METHODS: A clinical trial was carried out in paediatric patients (aged 5-15 years) with confirmed symptomatic G. duodenalis mono-infection. Patients were randomly as- signed to receive either MBZ [200 mg taken three times per day (TID) (n = 61)] or QC [2 mg/kg bodyweight tid (n = 61)], both for five days. Follow-up faecal samples were obtained at 3, 5 and 7 d after the end of the treatment. RESULTS: Although the frequency of cure was higher for QC (83.6%) than for MBZ (78.7%), the difference was not statistically significant (P > 0.05). Adverse events were reported more in the QC group (P < 0.05), all of them transient and self-limiting. CONCLUSION: Despite final cure rates ocurring lower than expected, the overall results of this study recon- firmed the efficacy of MBZ in giardiasis and also indicate that, although comparable to QC, at least in this setting the 5 d course of MBZ did not appear to improve the cure rates in this intestinal parasitic infection.
AIM: To compare the efficacy and safety of five days apostrophe therapy of mebendazole (MBZ) versus quina- crine (QC) on human giardiasis in children. METHODS: A clinical trial was carried out in pediatric patients (aged 5-15 years) with Confirmed symptomatic G. duodenalis mono-infection. Patients were randomly as-signed to receive either MBZ [200 mg three times per day (TID) (n = 61)] or QC [2 mg / kg bodyweight tid Follow-up faecal samples were obtained at 3, 5 and 7 d after the end of the treatment. RESULTS: Although the frequency of cure was higher for QC (83.6%) than for MBZ (78.7%) , the difference was not statistically significant (P> 0.05). Adverse events were reported more in the QC group (P <0.05), all of them transient and self-limiting. CONCLUSION: Despite the final cure rates ocurring lower than expected, the overall results of this study recon- firmed the efficacy of MBZ in giardiasis and also indicate that, although comparable to QC, at least in this setting the 5 d course of MBZ did not appear to improve the cure rates in this intestinal parasitic infection.