论文部分内容阅读
选择初发120例T2DM患者,经胰岛素强化治疗4周,比较治疗前、后空腹血糖(FBG)、空腹胰岛素(FINS)、空腹C-P(FC-P)、餐后2小时血糖(PBG)、餐后2小时C肽,糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IR)(HO-MA-IR=FBG X FINS/22.5)的变化。结果:经4周胰岛素强化治疗后,与治疗前相比FBG、PBG、HbA1c均显著降低,FINS、FC-P,餐后2小时C肽有明显升高,胰岛素抵抗指数(HOMA-IR)有明显降低,差异有统计学意义(P<0.05)。结论:对初诊断的2型糖尿病患者进行早期、短期胰岛素强化治疗,可使血糖迅速达标,消除高血糖的毒性副作用,可改善胰岛β细胞功能。
120 patients with T2DM were enrolled in this study. After intensive insulin therapy for 4 weeks, the fasting blood glucose (FBG), fasting insulin (FINS), fasting serum CP (FC-P), postprandial blood glucose Changes of C-peptide, HbA1c, HOMA-IR (HO-MA-IR = FBG X FINS / 22.5) after 2 hours. Results: After 4 weeks of intensive insulin treatment, the levels of FBG, PBG and HbA1c were significantly lower than those before treatment. FINS, FC-P and C-peptide 2 hours postprandial were significantly increased, and insulin resistance index (HOMA-IR) Significantly lower, the difference was statistically significant (P <0.05). Conclusion: Early and short-term intensive insulin treatment of newly diagnosed type 2 diabetic patients can achieve fast blood glucose compliance, eliminate toxic side effects of hyperglycemia and improve pancreatic β-cell function.