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本实验通过在体外培养的人滑膜细胞中加入不同浓度的组织胺的方法，观察到滑膜细胞分泌的透明质酸与培养液中的组织胺浓度呈正相关。从生化水平上探讨和揭示了炎性状态下透明质酸升高的机理，为用透明质酸作为关节炎诊断和治疗的指标提供了理论上的基础。
This experiment by in vitro cultured human synovial cells by adding different concentrations of histamine method, observed synovial cells secreted hyaluronic acid and culture medium histamine concentration was positively correlated. From the biochemical level to explore and reveal the inflammatory state of hyaluronic acid increased mechanism for the use of hyaluronic acid as an indicator of the diagnosis and treatment of arthritis provide a theoretical basis.