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目的探讨单、双眼皮与食管癌患病高风险的关系。方法采用问卷调查、家访(80%以上)和非条件Logistic回归分析方法,对2 262例病例组(经组织病理学确诊为食管鳞状细胞癌患者)及3 459例对照组(均经食管内镜检查确诊为非癌人群)单、双眼皮和其他临床资料等进行相关性分析。结果病例组单、双眼皮频率(58%vs.42%)高于对照组(51%vs.49%)(P<0.001),单眼皮人群患食管癌的风险性比双眼皮人群高(OR=1.29,95%CI:1.15-1.44,P<0.001)。年龄分层分析发现:45~64岁的单眼皮人群发生食管癌的风险高于同年龄段双眼皮人群(OR:1.26-1.61,95%CI:1.08-2.02)。结论单眼皮表型与食管癌患病高风险相关,提示单眼皮可作为食管癌高风险评估的危险指标之一,并为进一步研究皮纹与食管癌发生的相关分子机制,提供了线索。
Objective To explore the relationship between single and double eyelids and the high risk of esophageal cancer. Methods A total of 2 262 cases (patients with esophageal squamous cell carcinoma diagnosed by histopathology) and 3 459 controls (all underwent esophageal intubation) were enrolled in this study by means of questionnaires, home visits (over 80%) and unconditional Logistic regression analysis Microscopic examination diagnosed as non-cancerous) single, double eyelid and other clinical data correlation analysis. Results The single eyelid frequency (58% vs 42%) was significantly higher in the monocular eyelid patients than in the control group (51% vs 49%, P <0.001) 1.29, 95% CI: 1.15-1.44, P <0.001). Stratified by age stratified analysis showed that the incidence of esophageal cancer in single eyelid age group 45 ~ 64 years was higher than that in double eyelid age group (OR: 1.26-1.61, 95% CI: 1.08-2.02). Conclusions Single eyelid phenotype is associated with high risk of esophageal cancer, suggesting that single eyelid may serve as one of the risk factors for esophageal cancer risk assessment and provide clues for further study on the molecular mechanism of dermatoglyph and esophageal cancer.