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[目的]探讨肺减容术(LVRS)对慢性阻塞性肺疾病(COPD)患者肺功能以及血管内皮功能的影响.[方法]选择2013年2月至2017年6月本院收治的COPD患者62例,根据患者手术耐受性分为观察组和对照组各31例.观察组确诊为末期COPD后即行LVRS术,对照组确诊为末期COPD3个月后行LVRS术.比较两组在COPD诊断当天和随访3个月两个时间点血压、肺功能和内皮依赖性舒张功能(FMD).[结果]确诊后随访3个月,对照组血压值和肺余气量／肺活量比值增高明显增高、FMD下降;观察组血压值、FEV1预测值、FVC预测值、肺余气量／肺活量比值均较LVRS术前改善明显(P<0.05),而且观察组肺功能指标改善程度均高于对照组(P<0.05).观察组行LVRS术,FEV1或FVC每升高1%,FMD分别提高0.13%和0.11%(P<0.05).[结论]COPD患者行LVRS术可改善肺功能,并在此基础上进一步提高血管内皮功能.“,”[Objective]ToinvestigatetheeffectofLungvoLumereductionsurgery (LVRS)onpuLmonary functionandvascuLarendotheLiaLfunctioninpatients withchronicobstructivepuLmonarydisease (COPD).[Methods]Sixty-twopatientswithCOPDadmittedtoourhospitaLfrom February2013toJune2017weredi-videdintoobservationgroupandcontroLgroupaccordingtotheirsurgicaLtoLerance ,with31ineachgroup. LVRSwasperformedintheobservationgroupafterthediagnosisofend-stageCOPD,andLVRS wasper-formedinthecontroLgroup3monthsafterthediagnosisofend-stageCOPD.BLoodpressure,puLmonaryfunc-tionandendotheLiumdependentdiastoLicfunction (FMD)werecomparedbetweenthetwogroupsontheday ofCOPDdiagnosisandattwotimepointsof3monthsfoLLow-up.[ResuLts]After3monthsoffoLLow-updiag-nosis,thebLoodpressureandLungresiduaLvoLume／LungcapacityratioofthecontroLgroupincreasedsignifi-cantLyandFMDdecreased.ThebLoodpressurevaLue,FEV1predictivevaLue,FVCpredictivevaLue,Lungre-siduaLgasvoLume／LungcapacityratiooftheobservationgroupwereaLLimprovedcomparedwiththosebefore LVRS,theimprovementwassignificant(P<0.05),andtheimprovementofLungfunctionindexintheobser-vationgroupwashigherthanthatinthecontroLgroup(P<0.05).TheobservationgroupunderwentLVRS. Forevery1% increaseinFEV1orFVC,FMDincreasedby0.13% and0.11%,respectiveLy (P<0.05).[ConcLusion]LVRSinpatientswithCOPDcanimproveLungfunctionandfurtherimprovevascuLarendotheLiaL function.