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1968年,Berggard 等从肾小管性蛋白尿中分离得β_2-微球蛋白(以下简称β_2-m),并得到精制、纯化。临床上已将β_2-m 作为肾小管性蛋白尿诊断的一种标志,而且还将β_2-m 作为估价肾小球滤过率(GFR)的理想的内生性物质。β_2-m 在肿瘤和炎症等疾病时亦有所变化,不过这些水平改变无特异性,对诊断意义不大。β_2-m 在肾功能监测方面是一种敏感的指标。血清和尿液β_2-m含量虽微,但由于方法学的进展,已可适用
In 1968, Berggard et al. Isolated β 2-microglobulin (hereinafter referred to as β 2-m) from renal tubular proteinuria and purified and purified. Β_2-m has been clinically used as a marker for the diagnosis of renal tubular proteinuria, and β_2-m has also been used as an ideal endogenous material for assessing glomerular filtration rate (GFR). β_2-m in cancer and inflammation and other diseases have also changed, but these levels change non-specific, little significance for the diagnosis. β_2-m is a sensitive indicator of renal function monitoring. Serum and urine β_2-m content is small, but due to the progress of methodology, has been applicable