糖尿病肾病(DN)的发生和发展与多种因素有关,如糖脂代谢紊乱、血流动力学改变的影响等。但有报道,近1/3的糖尿病患者血糖控制良好,仍然并发DN,而另一些患者血糖居高不下,却不易发生DN。同时,在人群中也发现了DN的家族聚集性。这些现象表明单纯从环境因素解释DN的发病机制是不够 The occurrence and development of diabetic nephropathy (DN) are related to many factors, such as the disturbance of glucose and lipid metabolism and the influence of hemodynamic changes. However, it has been reported that nearly one-third of patients with diabetes mellitus have good glycemic control and are still complicated by DN, while others have high blood glucose levels, but are not prone to DN. At the same time, familial aggregation of DN was also found in the population. These phenomena suggest that it is not enough to explain the pathogenesis of DN solely from environmental factors