一氧化氮作为生物信使或效应分子在体内发挥重要的生理作用,且其体内水平异常与多种疾病的发生和发展密切相关。因此,一氧化氮供体型药物的研究备受关注。呋咱氮氧化合物即是一类重要的一氧化氮供体,其与某些药物分子偶联而合成的一氧化氮供体型药物可提高药物的药理活性。综述具不同药理作用的呋咱氮氧化物类一氧化氮供体型药物的研究进展。 Nitric oxide, as a bio-messenger or effector, plays an important physiological role in the body and its abnormal in vivo level is closely related to the occurrence and development of various diseases. Therefore, the research of nitric oxide donor drug has attracted much attention. Furosemide nitroxide is an important class of nitric oxide donors, and some of the drug molecules coupled to synthesize nitric oxide donor drugs can improve the pharmacological activity of the drug. This review summarizes the progress of studies on furazan - based nitric oxide donor drugs with different pharmacological effects.