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目的探讨黄甘颗粒对尖锐湿疣(CA)患者血清IFN-γ,IL-2水平的影响情况及对其抑制复发的作用。方法将入选的58例CA患者随机分为两组,各29例,全部患者予CO2激光术治疗,治疗组同时还予黄甘颗粒1粒(组分:黄芪30g,紫草15g,黄柏和甘草各10g)口服,3次/d,连用30d。结果两组患者治疗前、后血清IFN-γ和IL-2水平差异均有统计学意义(P均<0.05)。出院后3个月时,治疗组复发3例,对照组复发9例,差异也有统计学意义(P<0.05)。结论黄甘颗粒可提高血清IFN-γ和IL-2水平,对CA治疗和抑制复发有较好的临床疗效。
Objective To investigate the effect of Huanggan Granules on the serum levels of IFN-γ and IL-2 in patients with condyloma acuminatum (CA) and its role in the inhibition of recurrence. Methods Fifty-eight patients with CA were randomly divided into two groups (n = 29 in each group). All patients were treated with CO2 laser. The treatment group also received one capsule of Huang Gan (components: Astragalus 30g, Lithospermum 15g, Each 10g) orally, 3 times / d, once every 30d. Results The serum levels of IFN-γ and IL-2 in both groups before and after treatment were significantly different (all P <0.05). At 3 months after discharge, the treatment group recurred in 3 cases and the control group recurred in 9 cases, the difference was also statistically significant (P <0.05). Conclusion Huang Gan granules can increase serum levels of IFN-γ and IL-2, and have a good clinical effect on the treatment of CA and suppression of recurrence.