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目的:尿血安合剂联合来氟米特对IgA肾病患者安全性及VEGF、NF-κB表达的影响.方法:选择我院收治的90例IgA肾病患者作为本次研究对象,并分为45例对照组予来氟米特口服;45例观察组在来氟米特加尿血安合剂.观察两组患者安全性及VEGF、NF-κB表达.结果:治疗后对照组及观察组BUN分别为(6.32±1.26)mmo1/L及(5.23±1.21)mmo1/L,Scr分别为(75.32±12.52)μmo1/L及(71.62±13.34)μmo1/L,24hUP分别为(85.96±5.63)mg/24h及(46.92±4.52)mg/24h,Ccr分别为(44.51±5.16)ml/min及(44.51±5.16)ml/min,均显著低于治疗前(P0.05).治疗后对照组及观察组VEGF表达分别为(39.31±8.34)pg/ml及(28.20±11.64)pg/ml,NF-kB分别为(11.08±2.83)ng/ml及(6.58±2.19)ng/ml,均显著低于治疗前(P<0.05),两组比较,观察组VEGF及NF-kB表达均显著优于对照组(P<0.05).结论:尿血安合剂联合来氟米特治疗IgA肾病安全性高,疗效显著,能显著改善VEGF及NF-Κb表达.“,”Objective:To explore the effect of hematuria ann mixture combined with leflunomide on IgA ne-phropathy patients safety and VEGF ,NF- K B expression .Methods:90 cases of IgA nephropathy patients in our hospital divided into 45 cases of control group with random number table .Methods:To treat oral leflunomide ;45 ca-ses of the observation group:in the control group on the basis of an increase of hematuria mixture in the treatment of .The safety of the two groups and the expression of VEGF and NF- kB were observed .Results:After treatment , two groups of BUN ,Scr ,24hUP ,renal function indexes were significantly lower than those before treatment (P<0 .05) ,the Ccr index of the two groups of renal function were significantly higher than those before treatment (P<0 .05) .After the treatment ,the observation group after treatment control of the renal function index were signifi-cantly better than group (P< 0 .05) .Two groups of patients with urinary protein and red blood cells were signifi-cantly decreased ,and the observation group decreased significantly than the control group (P 0 .05) ,the control group of liver function before and after treatment were significantly higher ,and the ob-servation group was significantly higher than that of after treatment (P< 0 .05) .The two groups of patients after treatment ,VEGF and NF- K B expression was better than that before treatment ,the difference was statistically sig nificant(P< 0 .05) ,comparison between groups ,the observation group after the treatment of VEGF and NF- K B It was significantly better than the control group (P < 0 .05) .Conclusion:Hematuria ann mixture combined with le-flunomide in the treatment of IgA nephropathy with high safety ,obvious curative effect ,can significantly improve VEGF and NF- K B expression ,which is worthy of clinical promotion .