根据文献报导,神经氨酸酶(VCN)处理的自体肿瘤细胞注入患肿瘤的小鼠能免疫地导致肿瘤退化。这种处理细胞的免疫原性的增强有助于降低细胞的电荷以及暴露肿瘤的特异性移植抗原和/或新抗原。然而,也观察到肿瘤的退化跟从肿瘤细胞裂解的唾液酸量无关。它表明,尽管经过多次洗涤,VCN俯 It has been reported in the literature that administration of neuraminidase (VCN) -treated autologous tumor cells to tumor-bearing mice immunologically leads to tumor regression. The enhanced immunogenicity of such treated cells assists in reducing the charge of the cells as well as exposing the tumor specific transplant antigens and / or neoantigens. However, it was also observed that tumor regression was independent of the amount of sialic acid lysed from tumor cells. It shows that, despite repeated washing, the VCN pitched