海马是神经发生的主要区域之一,也是学习与记忆的关键脑区,海马功能的发挥源于其内部终身自我更新的神经干细胞,这群细胞在海马的迁移、增殖、分化成熟中有非常重要的影响,并整合到神经网络中,参与学习记忆的调节[1-3]。学习与记忆是人和动物获得和巩固新知识过程,是大脑重要的高级功能。学习与记忆功能是人和动物改变自身行为或形成新行为以适应自然环境的需要,是生物体进化的结果。海马齿状回的神经发生对大鼠长时程空间记忆能力的形成有 The hippocampus is one of the main areas of neurogenesis. It is also a key brain area for learning and memory. The function of the hippocampus is derived from the self-renewing neural stem cells within its own lifetime. These cells are very important in the migration, proliferation, differentiation and maturation of the hippocampus The influence, and integrated into the neural network, involved in the regulation of learning and memory [1-3]. Learning and memory are processes by which humans and animals acquire and consolidate new knowledge and are important advanced functions of the brain. The function of learning and memory is the result of the evolution of living organism, which is the need of humans and animals to change their behavior or form new behaviors to adapt to the natural environment. The hippocampal dentate gyrus occurs on the formation of long-term spatial memory in rats