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目的:研究分析中药联合激素冲击治疗肾病综合征的临床疗效。方法:将我院自2011年1月至2013年1月收治的由于各种原因导致的肾病综合征患者200例按随机数表法均分为对照组100例与实验组100例。对照组采取常规激素冲击治疗,实验组在采用科常规激素治疗基础上加用中药。2周为1疗程,观察患者治疗前后临床症状及肾功能的改变评价疗效。结果:治疗前组间差异无统计学意义(P>0.05),治疗后实验组尿蛋白少于对照组,血清蛋白高于对照组,组间差异有统计学意义(P<0.05);对照组总有效率为63.8%,低于实验组72.6%,组间差异有统计学意义(P<0.05);对照组水肿43例、库兴综合征11例、胸腔积液/腹水7例、发热/感染12例,发生人次高于实验组,分别为21例、2例、3例、3例,组间差异有统计学意义(P<0.05)。结论:中药联合激素冲击治疗肾病综合征取得良好疗效,减少激素副反应,提高用药依从性和治疗有效性。
OBJECTIVE: To study and analyze the clinical effects of traditional Chinese medicine combined with hormone therapy in the treatment of nephrotic syndrome. Methods: 200 patients with nephrotic syndrome who were treated in our hospital from January 2011 to January 2013 were randomly divided into control group (n = 100) and experimental group (n = 100) by random number table method. Control group to take conventional hormone therapy, the experimental group in the use of conventional hormone therapy based on the use of traditional Chinese medicine. 2 weeks for a course of treatment, observation of patients before and after treatment of clinical symptoms and changes in renal function evaluation of curative effect. Results: Before treatment, there was no significant difference between the two groups (P> 0.05). After treatment, the urinary protein in the experimental group was less than that in the control group, and the serum protein was higher than that in the control group. There was significant difference between the two groups (P <0.05) The total effective rate was 63.8%, lower than the experimental group 72.6%, the difference between the groups was statistically significant (P <0.05); the control group, 43 cases of edema, Cushing’s syndrome in 11 cases, pleural effusion / ascites in 7 cases, fever / Infections occurred in 12 cases, which were higher than those in the experimental group, 21 cases, 2 cases, 3 cases and 3 cases, respectively. The difference was statistically significant (P <0.05). Conclusion: Chinese medicine combined with hormone therapy for nephrotic syndrome and achieved good results, reduce side effects of hormones and improve drug compliance and the effectiveness of treatment.