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目的探讨乙型肝炎后肝硬化伴发糖代谢异常的临床表现。方法选择我院2010年1月—2012年12月117例乙型肝炎后肝硬化患者,并对其予以葡萄糖耐量试验,根据试验结果分为糖耐量减退组、糖耐量正常组、糖尿病组,每组39例;并选取健康体检者39例设为正常组。分析对比各组血糖、胰岛素、C肽指标空腹和餐后2 h值,并计算胰岛素敏感性(IS)、β细胞功能指数(HBCI)值。结果正常组与肝硬化糖耐量减退组、糖尿病组的血糖、胰岛素水平、C肽、胰岛素敏感性在指标检测中差异有统计学意义(P<0.05)。结论乙型肝炎后肝硬化伴发糖代谢异常情况需给予血糖检测,尽早诊断,以合理措施保持血糖平稳性,提高患者生活质量。
Objective To investigate the clinical manifestations of post-hepatitis B cirrhosis with abnormal glucose metabolism. Methods A total of 117 hepatitis B cirrhosis patients from January 2010 to December 2012 in our hospital were selected and subjected to glucose tolerance test. 39 cases were selected; 39 healthy subjects were selected as normal group. The levels of blood glucose, insulin, C-peptide in fasting and postprandial 2 h were analyzed and compared, and insulin sensitivity (IS) and β cell function index (HBCI) were calculated. Results The blood glucose, insulin, C-peptide and insulin sensitivity of normal group and cirrhosis with impaired glucose tolerance group and diabetic group were significantly different (P <0.05). Conclusion Hepatitis B cirrhosis with abnormal glucose metabolism should be given blood glucose testing, early diagnosis, with reasonable measures to maintain blood sugar stability, improve patient quality of life.