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目的研究人白细胞抗原-G(HLA-G)基因多态性与单纯疱疹病毒性脑炎(HSE)发病风险的相关性。方法应用聚合酶链反应检测HSE患者及正常人的HLA-G基因14 bp插入/缺失(ins/del)多态性分布,分析HLA-G基因型、等位基因与HSE发病风险的关系。结果 HLA-G14 bp的3种基因型在HSE组和对照组的分布差异有统计学意义(P=0.007),并且HSE组del/del基因型频率较对照组明显升高(OR=5.56,P=0.018)。等位基因频率的分析发现HSE组14 bp缺失(-14 bp)频率较对照组高(78.70%vs.67.16%),两组差异有统计学意义(OR=1.81,P=0.004)。结论 HLA-G 14 bp插入/缺失多态性可能与HSE的发病相关,其中14 bp缺失可能是HSE发病的一个遗传危险因素。
Objective To study the association between human leukocyte antigen-G (HLA-G) gene polymorphism and the risk of herpes simplex encephalitis (HSE). Methods The 14 bp insertions / deletions (INS / del) polymorphisms of HLA-G gene in HSE patients and normal controls were detected by polymerase chain reaction (PCR). The association between HLA-G genotype and allele and the risk of HSE was analyzed. Results The distribution of HLA-G14 bp genotypes in HSE group and control group was significantly different (P = 0.007), and the frequency of del / del genotype in HSE group was significantly higher than that in control group (OR = 5.56, P = 0.018). Allele frequency analysis revealed that the frequency of 14 bp deletion (-14 bp) in HSE group was higher than that in control group (78.70% vs.67.16%). There was significant difference between the two groups (OR = 1.81, P = 0.004). Conclusion The HLA-G 14 bp insertion / deletion polymorphism may be associated with the pathogenesis of HSE. The deletion of 14 bp may be a genetic risk factor for HSE.